Follicular mucinosis is a term that encompasses three related entities. Alopecia mucinosa, Urticaria-like follicular mucinosis, and cutaneous lymphoma related. On hair-bearing skin (e.g. scalp), overlying alopecia is notable, hence the term “ alopecia mucinosa” (see Figure 5). Plaques are often composed of densely. Alopecia mucinosa is a skin disorder that generally presents, but not exclusively, as erythematous plaques or flat patches without hair primarily on the scalp.

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It is common practice that in regions endemic for leprosy, such as India, children and young adults who present with single hypoesthetic lesions on the face are not biopsied but treated on clinical suspicion alone and because they respond to MDT would be labeled as leprosy.

If associated with an underlying neoplastic or inflammatory disorder, treatment of the associated disease is warranted. No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC.

This lesion had been diagnosed as follicular mucinosis with folliculo-tropic mycosis fungoides, in the USA. Case 2 A year-old girl presented in Marchwith hair loss over left eyebrow and dry hypopigmented skin of adjacent forehead. Secondary alopecia mucinosa should be treated appropriately for the underlying skin disease, particularly if it is cutaneous T-cell lymphoma. Home About Us Advertise Amazon. Journal List Indian J Dermatol v.

DermNet NZ does not provide an online nucinosa service. An electron microscopic study. These lesions, however, mycinosa always single and show rapid and complete response to antileprosy treatment. Who is at Risk for Developing this Disease?

Parker SR, Murad E. Suggested therapies are based on anecdotal reports or small case series. Of note, FM may resolve spontaneously. For more numerous or widespread lesions, or if the patient shows no response or is intolerant to the options above, the following are first-line oral therapeutic options: Follicular mucinosis is a xlopecia reaction pattern wherein variable amounts of epidermally derived mucin accumulate within follicular infundibula and the outer root sheath epithelium.

With the good response to MDT in the previous 2 cases it was decided to start him also on MDT, however, as he was shortly returning to the USA, he was started on ROM therapy rifampicin mg, ofloxacin mg, minocycline mg to be taken once a month for 6 months.


Sensations were mildly impaired over the site but no thickened nerve was palpable.

She completed 6 months of MDT in Decemberat which alopceia the lesion had cleared completely with regrowth of all hair [ Figure 1b ]. Diagnosis confirmation In any subtype of FM, lesional skin polymerase chain reaction PCR based molecular testing for T-cell clonality may be positive, thereby suggesting monoclonality of the infiltrating T lymphocytes.

Alopecia mucinosa is diagnosed by its clinical appearance and supported by histopathological findings on biopsy:.

Follicular Mucinosis (Alopecia Mucinosa)

J Am Acad Dermatol. No granulomas were seen. A case of follicular mucinosis treated successfully with minocycline. A retrospective analysis mucimosa histopathology of 64 cases of lepra reactions. Inflammatory diseases of hair follicles, sweat glands and cartilage; pp.

Therefore it is too much of coincidence to consider that the response in all patients was due to natural remission, and it is most likely that it was the oral treatment wlopecia brought about healing of the lesions.

Pathology Outlines – Alopecia mucinosa

Case Reports Xlopecia 1 A year-old boy presented in Septemberwith a hypopigmented and hypoaesthetic shiny patch on the left cheek of few months duration.

It is possible that these activated T lymphocytes may cause mucin accumulation in the affected follicles, and it is conceivable that follicular mucinosis may occur in nucinosa of leprosy without granulomas. A month later the patch had enlarged minimally, alopeia surface was dry and showed follicular prominences, however, no erythema was seen [ Figure 1a ]. Follow up in September 09, 3. Aloepcia called follicular mucinosis Edematous and erythematous plaques of alopecia on head and neck Children: Alopecia mucinosa alopeciq been divided into the primary or idiopathic variety and the secondary type associated with cutaneous T cell lymphoma.

Etiology The etiology is not known. Views Read Edit View history. Dapsone has been reported to clear Follicular mucinosis and the presence of dapsone in the MDT may be the agent responsible for healing in cases 1 and 2. Alopecia mucinosa most commonly affects face, neck and scalp, but any part of the body may be affected. Follicular infundibulum keratinocytes and outer root sheath are separated by pools of mucin Mixed infiltrate of lymphocytes, histiocytes and conspicuous eosinophils Marked follicular dilation with cyst formation and perifollicular scarring Both the dermis and and affected epithelium are typically infiltrated by lymphocytes, histiocytes and eosinophils In cases associated with lymphoma, atypical lymphocytes, convoluted lymphocytes, large transformed cells and mitotic figures may be seen.


The etiology is not known. Clinical, histological and immunological remission with minocycline. Photodynamic therapy is an option, but availability is more limited and may be more costly. Sign up for our Email Newsletters. If recurrence is noted upon withdrawal, consider reinstitution of either the same or a new therapy.

He too responded completely within 3 months with rifampicin, ofloxacin, minocycline ROM treatment, which was given once monthly for a total of 6 months and remains free of disease since the past 1 year. Alopecia areata totalis universalis Ophiasis Androgenic alopecia male-pattern baldness Hypotrichosis Telogen effluvium Traction alopecia Lichen planopilaris Trichorrhexis nodosa Alopecia neoplastica Anagen effluvium Alopecia mucinosa cicatricial alopecia: Images hosted on other servers: Alopecia Mucinosa [Accessed 24 August ].

Koilonychia Nail clubbing behavior: Indian J Dermatol Venereol Leprol.

Follicular Mucinosis (Alopecia Mucinosa)

In sum, we present three cases of Alopecia mucinosa, who presented with single lesions on the face, had follicular mucinosis on biopsy and who healed rapidly and completely with initiation of antileprosy treatment.

Few of the follicular infundibula showed features of follicular mucinosis with mild spongiosis, separation of the keratinocytes from one another, and clear spaces between the keratinocytes, which contained wisps of light blue-gray mucin.

The skin lesion had completely healed after months of starting the treatment. Accessed December 31st, Alopecia mucinosa occurs when mucinous material accumulates in the hair follicles and sebaceous glands.

J Cut Med Surg. Isotretinoin is pregnancy category X.